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A water molecule in the close vicinity of Gln390 hydrogen bonded to the hydroxyl group of Ser388 and -amino group of Gly484 has been reported to enhance nucleophilicity of OG atom of Thr391 that appears crucial in autoprocessing (Figure 2

(2) Promote cartilage repair by activating the TGF- /Smad3 signaling pathway

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Thus, the authors attributed the ability of AA8 cells to resist radiation-induced mutation to the elevation of GPx activity by selenite