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Nat Struct Biol 5: 247249
The advent of convenient laboratory assays revealed mild to moderate elevation of blood homocysteine concentrations in association with vitamin insufficiencies (i.e., folate, vitamin B12, vitamin B6, and riboflavin), several diseases and disorders, some pharmaceuticals, and lifestyle factors (7)
doi: 10.1038/s41598-018-26882-8 6 CuiYYangDWangWZhangLLiuHMaSet al

NAD+ is a critical coenzyme involved in hundreds of metabolic reactions, energy production, DNA repair, and cellular aging pathways