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Combined treatment with low doses of the SIRT1-specific activator SRT2104 and the LDHA inhibitor oxamate exerted significant antitumor effects on GC cells, with limited adverse effects on normal gastric cells

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Interestingly, the same Abdeg was shown to improve radioimaging by shortening the in vivo plasma half-life of a radioactively labeled, tumor-specific human IgG1 mAb in mice, resulting in reduced systemic exposure and thereby improving the imaging contrast in positron emission tomography [121]

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Tier 3 (Promising but early): Some human evidence, but outcomes are inconsistent or limited

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Materials and Methods 2.1

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