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Animal and surgical procedures The Yangzhou University School of Medicines Ethics Committees norms and regulations were followed in all animal operations (202,402,101)

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Oestrogen-receptor-positive breast tumours harbouring a sporadic NF1 mutation have a poor outcome, 90 and depletion of oestrogen through ovariectomy in a NF1 -loss-driven rat model of breast cancer leads to tumour regression