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The tumor suppressor p53 activates GLS-2 expression, regulates intracellular ROS levels and reduced/oxidized GSH ratios, and removes intracellular ROS to protect cells from genomic damage and ROS-sensitive apoptosis [18, 19]

321(g)(1), because they are intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease and/or intended to affect the structure or function of the body." FDA's letters to the other manufacturers are similar in their complaints about why their products fall under the agency's regulatory oversight and why the companies are not allowed to market them, despite their oft-cited claims that the products, especially the triple agonists, are for research only

5 Synergistic therapeutic strategies targeting RCD pathways and immune checkpoint inhibitors Regulated cell death (RCD) pathways, including ferroptosis, pyroptosis, and necroptosis, have emerged as crucial modulators of antitumor immunity, serving as a bridge between tumor cell elimination and immune response activation (123)

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