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Antibiotics profoundly disrupt gut microbiota, transiently reducing IS/pCS production for weeks post-treatment, and phosphate binders such as sevelamer bind IS in the gut, lowering circulating levels independent of microbial production changes

in practice, 70% to 85% of FIMs that reach final IC are approved , since the prior approval gates have already filtered out the weakest candidates

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Annu Rev Pathol 18:95121 Yue D, Zeng C, Okyere SK, Chen Z, Hu Y (2021) Glycine nano-selenium prevents brain oxidative stress and neurobehavioral abnormalities caused by MPTP in rats