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Dectin-1 also modulates the expression of cytokines via activating the nuclear factor of activated T cells (NFAT) that regulates IL-2, IL-10, and IL-12 p70 production (174)

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These doses are too low to produce significant appetite suppression or meaningful weight loss in most people

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The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability

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[DOI] [PMC free article] [PubMed] [Google Scholar] Mhamdi A., Mauve C., Gouia H., Saindrenan P., Hodges M., Noctor G

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