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Importantly, the IGF-1R is also critical for the increased expression of StAR under FSH stimulation, which is required for mitochondrial transport of cholesterol for the first step of sex steroid synthesis, pregnenolone production (60)

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16 hr half life desipramine (generic, Norpramin ) is an active metabolite of imipramine that selectively inhibits NET, with minor effects on SERT
