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Data normality was assessed by the Shapiro-Wilk test, and appropriate tests were chosen according to data distribution

The number of times that the motif C-X-X-C appears in human genes are near 19,000 in about 6,000 proteins (www.uniprot.org), but note that not all of these motifs will appear in native proteins, and not all proteins having the motif C-X-X-C will be an oxidoreductase (Table 5)

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