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BER enzymes are primarily targeted at removing N7-MeG and N3-MeA lesions, subsequently repairing the DNA through the collaborative action of DNA polymerase and DNA ligase, thus restoring the DNA strand to its original, non-damaged state [165]
Phillips MM
Therefore, these results indicate that, although DNA repair is an important mechanism, other mechanisms may play a primary role in determining resistance to cisplatin, especially in NCI H23 cell line
