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The peptide activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in a dose-dependent manner, leading to nuclear translocation and activation of transcription factors including c-Fos, c-Jun, and early growth response-1 (Egr-1) that drive expression of genes involved in cell growth, migration, and angiogenesis
doi: 10.1134/S1990519X07010063
[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Margis R., Dunand C., Teixeira F.K., Margis-Pinheiro M
Additionally, inflammation might compromise the overall health of the gut lining, which could indirectly affect histamine regulation
