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Negative effects of alcohol 2 that contribute to a hangover include: Accumulation of toxic byproducts, including acetaldehyde Nutrient depletion Hormonal imbalances, including increased cortisol (a stress hormone) and lower serotonin (affecting your mood) Dehydration Inflammation Poor sleep quality When you drink, your liver works overtime to metabolize alcohol into acetaldehyde, a toxic byproduct that contributes to hangover symptoms, including headaches, nausea, and fatigue

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Kradttir R, Cavelier P, Bergersen LH, Attwell D

There was a steady increase in mean sensitivity during the treatment period in each cohort, which was greatest in cohort 3 at 0.15 dB/month (p = 0.008)