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It can have both a negative effect, such as HFD inducing metabolic endotoxemia, or a positive effect, such as a diet rich in plant polyphenols or fermented dairy products, increasing the expression of TJ proteins and promoting the development of beneficial bacteria

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Neuroimaging biomarkers also offer substantial predictive value, for example, reduced DAT uptake on PET scans can detect dopaminergic deficits 510 years before clinical symptom onset and help predict conversion to manifest PD [248, 249]