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therefore, MAO-driven metabolism of substances such as dopamine, serotonin, norepinephrine, and tyramine normalizes only after new MAO is synthesized, and this process takes about 2 weeks to be complete after the MAOI has been washed out of the body

This assertion was further verified by a series of intervention studies, where improvement of lipid solubility and intestinal permeability as well as inhibition of intestinal flora increased the relative bioavailability to different extents without being changed by P-gp inhibition

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