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Common ingredients in pre-workouts include: L-Citrulline Small studies using lower doses of L-citrulline malate have shown some improvements in cycling performance and muscle soreness, though some larger-scale meta-analyses of aerobic performance have revealed mixed results, even with higher doses.35 36 Other large reviews have been more positive, especially at 8g/day and above.45 The trend in the literature seems to indicate that higher doses would be more effective, though many pre-workout supplements offer 6g or less

Peer review Peer review information Nature Communications thanks Carolyn Phillips and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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