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Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Praderwilli syndrome
In a study with senescence-accelerated mice and normal aging controls, treatment with SF for about a year significantly improved long-term memory and increased hippocampal mRNA and protein levels of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1) and mitochondrial transcription factor A (TFAM), both of which are master regulators of mitochondrial biogenesis
Key points The fate of T cell differentiation can be determined by the activity of various metabolic pathways in the cell, reflecting the central role of metabolism in controlling T cell plasticity
