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It is worth noting the magnitude of reduction of CCL3 mRNA levels by B12 in this group, which was accompanied by the reduction of their intracellular protein levels

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Several possible reasons for the lack of efficacy of antioxidants in clinical trials include (i) insufficient antioxidant levels in the target organ, especially in the nervous system, because an integrated bloodbrain barrier (BBB) is a major obstacle to delivering desired substances, including antioxidants, into the CNS