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More recently, decrease in ET in the whole blood of human subjects has identified it as a potential marker of frailty (66)

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It is also important in brain function and controlling inflammation.[ref] In men, estrogen is also necessary at low levels in the production of sperm

An alternative folate- and vitamin B12-independent reaction utilizes betaine (a metabolite of choline) as the methyl donor to convert homocysteine to methionine
