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Possibly, with respect to the underlying disease (which was markedly counteracted in BPC 157 rats), more activity of eNOS (the constitutive isoforms instantly increase along with COX2), and more activity of nNOS (NO produced by nNOS is thought to mediate synaptic plasticity and neuronal signaling) [103,104], may be intrinsic effects of BPC 157

10.3390/cells12212565 [DOI] [PMC free article] [PubMed] [Google Scholar] 89.Zheng X, Han D, Liu W, Wang X, Pan N, Wang Y, Chen Z (2023) Human iPSC-derived midbrain organoids functionally integrate into striatum circuits and restore motor function in a mouse model of Parkinsons disease

Acta Neuropathol 110(3):247254

The role of apoptosis is well-established, and its activation can decrease tumor formation