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Description
Mutants and redheads showed an increased analgesic response, which the authors confirmed was likely a true pharmacodynamic, rather than metabolic/pharmacokinetic effect, as circulating levels of the drug were similar in both groups [27]

Ghanem, G., Verstegen, J., De Rijcke, S., Hanson, P., Van Onderbergen, A., Libert, A., et al
doi: 10.1002/hep.26057
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Hazen and his team published a study showing how researchers had designed a potential new class of drugs for prevention of heart disease and clotting risk by interrupting the microbial pathway by which choline is converted into TMAO
