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Each vitamin E molecule comprises a chromanol ring with a hydroxyl group that can donate a hydrogen atom to reduce free radicals and a hydrophobic side chain that permits entry into cellular membranes

The oxidative damage mediated by ROS resulting in the defect in control of apoptosis or programmed cell death and delayed clearance of apoptotic cells may prolong interaction between ROS and apoptotic cell macromolecules generating neoepitopes that subsequently broad spectrum of autoantibody formation leading to the tissue damage in SLE [6,7]

doi: 10.1016/j.steroids.2011.11.014 49 PalombaSFalboAZulloFOrioJR