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High-dose IV vitamin C reaches tissue concentrations not achievable orally

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It was demonstrated that methylation sites (H4K20me2 and HK20me3) changed during aging and AD, while histone H3 acetylation increased only in AD (H3K27ac and H3K9ac) and was associated with such biological processes as transcription, nucleic acid metabolism, and Wnt signaling pathways that are involved in neurodegeneration, as well as synaptic transmission, neuronal death, immune response, and oxidative stress [107]

Angelini C, Pennisi E, Missaglia S, Tavian D (2019) Metabolic lipid muscle disorders: biomarkers and treatment