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The study, available in the Journal of Child and Adolescent Psychopharmacology and funded by an Autism Speaks grant, was the worlds first placebo-controlled, blinded trial of methyl B12 injections

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Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials

When you take pills or oral medicines, it takes time for them to work through your system and into your blood