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Moreover, in the bio portal TGCA AML cohort, overexpression of both GPX1 and GPX4 which is found in a significant subset of patients is associated with a poor prognosis [36]

As such, the formation of the hydroquinoneGSH conjugate cannot be considered as a detoxification mechanism itself, causing the resulting adducts to be nephrotoxic and myelotoxic

5.3.5 Inhibition of cell invasion and migration Artesunate inhibits the proliferation, migration, and invasion of A549 and H1299 cells and induces their apoptosis, possibly due to reduced HuR and MMP-9 protein expressions (Hu et al., 2022)

Vitamin C also regenerates glutathione and supports collagen, so the two work as a pair rather than in isolation