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Thus, the transition from crystal deposition to acute inflammation can be conceptualized as a two-hit process: First hit: MSU crystal deposition on cartilage surfaces activates synovial fibroblasts to release CCL2/MCP-1, recruiting monocytes and establishing subclinical inflammation

recommend the inclusion of MMA as part of a comprehensive diagnostic panel alongside total serum B12, holotranscobalamin (active B12) and homocysteine to monitor B12 status (Fedosov et al

Animal studies show embryo-fetal toxicity

By Helene P
