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Current research has expanded beyond the previously emphasized Human Leukocyte Antigen DR 1 (HLA-DRB1) to uncover several new key genetic risk factors, including TET2 (10-11 Translocation 2), Foxp3 (Forkhead Box P3), ATXN1 (Ataxin-1), RP11-326C3.13, TNFSF14, Dysferlin (DYSF), and Zinc Finger Protein 638 (ZNF638) (129133)

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By contrast, the toxin may act slowly over time

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