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Researchers should document baseline measurements before starting a protocol, track relevant metrics at regular intervals, and note any side effects or unexpected responses

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While no major safety flags have emerged from either the scientific literature or widespread anecdotal use, the absence of large-scale human data means users should proceed carefullyespecially if considering high doses or long-term use

18 A study in 2003 compared oral versus sublingual cyano-B12 (500 g per day for 8 weeks), and found that both increased B12 levels significantly without a significant difference between the two