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In addition to energy and cognitive support, the mast cell-stabilizing and tissue-repairing properties of Buffered Vitamin C target a different subset of systemic symptoms: Histamine Intolerance and Allergic-Like Flares: By acting as a cofactor for the DAO enzyme and stabilizing mast cell membranes, Vitamin C helps accelerate the breakdown of circulating histamine and prevents new histamine release

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25-27 Furthermore, IC/BPS patients displaying widespread pain showed multiple indications of central neurobiological pain sensitization, correlating with quantitative sensory testing, fMRI (functional magnetic resonance imaging), and inflammatory markers