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However, this is a long chain of indirect influence rather than a cause-and-effect link

doi: 10.3389/fphar.2025.1610793 Received 12 April 2025 Accepted 21 July 2025 Published 18 August 2025 Volume 16 - 2025 Edited by Michael Heinrich, University College London, United Kingdom Reviewed by Sena Ardicli, Bursa Uluda University, Trkiye Huiwen Pang, University of Queensland, Australia Updates Copyright 2025 Zedan, El-Moslemany, Bahnasy, Eldamaty, Ibraheim, Alotaibi, Abdelmegeid, Shukry and Elolimy

Low active folate levels can lead to a build of of homocysteine and lack of methionine in the body and can lead to several health problems (more on high homocysteine levels can be found here)

Research suggests DSIP may modulate stress hormone levels, including potential effects on cortisol and ACTH