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Mn activated LRRK2 kinase via phosphorylation of the serine 1292 residue, and two exceptionally efficient inhibitors (GSK2578215A and MLi-2) of LRRK2 were able to inhibit its manganese-induced activation manifested by suppressed apoptosis in microglia and macrophages and decreased Bax, a proapoptotic member of the Bcl-2 family
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Identification of four novel human G protein-coupled receptors expressed in the brain
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