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Description
Effects of methyl-B12 on the in vitro immune functions of human T lymphocytes

Diabetic Intervention with Vitamins to Improve Nephropathy (DIVINe) was a double blind RCT on a population of 238 patients with diabetic kidney disease randomized to receive 2.5 mg folic acid plus 25 mg vitamin B6 plus 1 mg vitamin B12, or placebo (mean eGFR was 64 mL/min in treatment group and 58 mL/min in the placebo group)

It aids in the production of serotonin and dopamine, neurotransmitters that help regulate mood
Homocysteine can act directly on glomerular cells inducing sclerosis, and it can initiate renal injury by reducing plasma and tissue level of adenosine