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Functionally, zone 1 hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, b-oxidation of fatty acids, and cholesterol synthesis, while zone 3 cells are more important for glycolysis, lipogenesis, and cytochrome P-450based drug detoxification

The choice of neurogenic markers in this study was based on their established roles in neural development and plasticity

Enhanced blood flow means working muscles hit their limit later, recovery happens faster, and cardiovascular stress is reduced during hard efforts

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