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Abstract In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes

Since NSP activity is the core pharmacodynamic indicator for evaluating DPP1 inhibition effects, developing simple and accurate NSP activity detection methods is crucial for clinical research and individualized treatment ( 9.2 Future research directions Development and validation of biomarkers constitutes a key element for achieving precision treatment