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Food & Drug Administration (FDA) issued a Drug Safety Communication warning that serious breathing difficulties may occur in patients using gabapentin (Neurontin, Gralise, Horizant) or pregabalin (Lyrica, Lyrica CR) who have respiratory risk factors

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A complementary study revealed that activation of microglia in vitro, following NMDA receptor stimulation, was accompanied by secretion of ROS that was toxic to neurons [265]