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Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT
This study directly links lactate metabolism to epigenetic modification and finds that accumulated lactate can catalyze the lactylation of histone H3K18, thereby forming an epigenetic-metabolic positive feedback loop that promotes the expression of oncogenes
doi: 10.1016/j.colsurfb.2012.07.005 [DOI] [PubMed] [Google Scholar] 148.Ponsart S, Coudane J, Vert M
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