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doi: 10.1038/nature00935

Moreover, statins inhibit the activity of -hydroxy--methylglutaryl-CoA reductase to reduce cholesterol levels and stimulate the liver to uptake LDL from the blood, which has a notable impact on preventing cardiovascular diseases especially coronary heart disease (134,135)

Bruising at the needle site is common and not usually a concern

One such example is the neurological epigenetic disease called Angelman syndrome, that results from epigenetic silencing of the paternal UBE3 allele combined with a mutation or deletion in the maternal UBE3 allele, resulting in loss of E3 ubiquitin ligase, leading to multiple neuronal defects like epilepsy, ataxia, etc