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The following adverse event rates were reported at any time following initial injection and prior to reinjection or study exit (median duration of 44 weeks of exposure): UTIs (49%), urinary retention (17%), constipation (4%), muscular weakness (4%), dysuria (4%), fall (3%), gait disturbance (3%), and muscle spasm (2%)

Changing guidelines The ACRs 2012 guidelines for managing rheumatoid arthritis recommended combining methotrexate with other DMARDs, particularly sulfasalazine and hydroxychloroquine, a combination called triple therapy

Avoid taking high doses of vitamin B12 or multivitamins unless your doctor recommends them

Rocio T Martinez-Nunez, et al