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doi: 10.1016/j.ccr.2012.11.020
These are part of the nuclear receptor superfamily of transcription factors
Various exercise studies have observed improved endogenous defence in rodents following training [13,14,15,16,17], along with reduced ROS production at the same absolute exercise workload during following training [18]

This is based on the observation that the livers of GCLM KO mice in all diet groups have high levels of active (phosphorylated) LKB1, a redox-sensitive kinase and the primary hepatic AMPK kinase 24