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Carnitine is a non-essential nutrient, which is derived from amino acids
OCTN2 contains a glucose-transporter signature motif between transmembrane domains 2 and 3 in which substitution of arginine 169 with glutamine, proline or tryptophan (all identified in patients with primary carnitine deficiency) impairs transporter function without impairing maturation to the plasma membrane [95]
doi: 10.1172/JCI113570 73
