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Humans cant produce it endogenously

Phagocytic cells (neutrophils, macrophages, and monocytes) while defending the CNS against invading microorganisms or clearing the dead cell debris produces ROS [24]

174 UenoD.IwashitaT.ZhaoF

A study based on M1/M2-macrophage function in relation to DAMPs and autophagy shows that M1 macrophages and their associated factors, including IFN-, MCP-1, IL-1, IL-6, and TNF-, are increased in the early stages of APAP-induced hepatotoxicity and are involved in tissue damage or inflammation, while M2 macrophages and related factors IL-4, IL-10, and TGF-1 subsequently appear in the late stages [57]