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Circulation 107 , 24802486
No significant toxicity indicators reported during the preclinical trials
Mental health issues are serious, but what other reasons, I'd love your thoughts on that, on the mental health part
For instance, in salicylate-induced tinnitus rats, significant upregulation of the microglial marker Iba1 occurs in the primary AC and medial geniculate body, and significant upregulation of the astrocytic marker GFAP occurs in the primary AC, alongside increased morphological complexity indicative of an activated state (Xia et al., 2020)
