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On the other hand, PDE5 degrades cGMP, which disrupts the vasodilatory pathway initiated by NO
HNF-1 is involved in a regulatory loop with HNF-4 controlling many genes involved in liver function such as the gene (SLC2A2) encoding GLUT2 and the gene (PKLR) encoding liver pyruvate kinase (L-PK)

95% confidence intervals 1.424.02
PLoS One 10 (10), e0141652