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IDD is a leading cause of chronic lower back pain with pathological mechanisms involving nucleus pulposus cell (NPC) apoptosis, extracellular matrix (ECM) degradation, an imbalanced inflammatory microenvironment and oxidative stress damage (12,13)

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Montenegro Junior, Type B insulin resistance syndrome: a systematic review

A study comparing GSH, GSSG, GPx and GR levels in the caudate region of the brain after death in schizophrenia patients and normal subjects showed that the schizophrenia group had significantly lower levels of GSH, GPx, and GR than the control group, which did not have any psychiatric disorders (24).The potential mechanism by which the reduced level of GSH affects the morphology of neurons may be through oxidative stress damage inducing lipid peroxidation, the protein denaturation, which further leads to cell membrane alterations and cytoskeletal changes, affecting the normal functioning of neuronal cells in the corresponding brain regions involved in schizophrenia (25)