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There are many theories regarding the causes of Vitiligo and the process through which this disease spreads, however studies have demonstrated that the loss of cutaneous melanocytes can be caused by decreased circulating and lesional skin levels of the naturally occurring melanocortin peptide hormone, alpha-melanocyte (-MSH)

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Therefore, in this review the term bivalent ligand will be used exclusively for ligands which target two orthosteric binding sites on two different receptors

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Interestingly, wah-1(bon89) mutants showed a stronger upregulation of [gst-4p::GFP::NLS] compared to controls when grown on OP50 rather than HT115 (Fig

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