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David Sinclair: For most of us, yes

This seems very significant in the study of AD because several neurotransmitters are defective in this disease

Just suddenly it showed up in a bunch of products with many of the brands saying it works just like a retinoid, which to me implies that it works via the same mechanism (again, which I cant confirm)

Because NNMT activity intersects methyl donor utilization and nicotinamide handling, experimental inhibition can be used to probe pathway level relationships among methyl economy balance, NAD+ salvage flux, and downstream metabolic signaling in a range of preclinical systems