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5 , 209ra151 (2013)

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Serum electrolytes, particularly potassium should be monitored closely - Anticoagulants: can increase or decrease the effects being necessary a dosage adjustment - Somatotropin: by inhibiting the response to this hormone Pregnancy and lactation Pregnancy: Safe use of this medicine in pregnancy has not been established

2.5.3 Extrapolation of animal data to man The use of animals has been essential to help define the molecular basis and the progression of model nephropathies, but it may be inappropriate to extrapolate animal toxicology data directly to man because of marked species, strain, dietary, and sex differences