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For example, leukemia linked to chronic benzene exposure may develop within a few years, whereas cancers caused by asbestos or arsenic often take several decades to manifest, even after exposure has ceased [246]

found in their study that in clear cell renal cell carcinoma (ccRCC) tumor cells, endogenous Gln metabolism might reduce the anti-tumor effectiveness of T cells by promoting the Treg cell response ( 2.1.4 Regulation of tumor cell redox homeostasis Gln regulates the redox status of cancer cells by influencing the production of mitochondrial ROS

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Certain populations, including the elderly, vegetarians, and those with gastrointestinal disorders, may be at a higher risk of deficiency due to inadequate dietary intake or absorption issues