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Alternative Routes of Administration & the First-Pass Effect There are several reasons for different routes of administration used in clinical medicine ( Table 33 )for convenience (eg, oral), to maximize concentration at the site of action and minimize it elsewhere (eg, topical), to prolong the duration of drug absorption (eg, transdermal), or to avoid the first-pass effect (sublingual or rectal)

Duration: A complete course may include 10 to 30 sessions, depending on the individuals response and skin type

Moreover, certain medications, including metformin, proton pump inhibitors, and antacids may also reduce your bodys ability to absorb vitamin B12 from your diet (1, summary Vitamin B12 deficiency can manifest itself through a variety of symptoms

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