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Hypoxia can also directly increase fatty acid synthesis by upregulating key enzymes such as fatty acid synthase (FAS) [12] and can increase flux through additional metabolic pathways that fuel lipid synthesis, including reductive carboxylation of glutamine [13]
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Experimental evidence suggests that changes in the lipid composition of the plasma membrane, as a result of PLC activation, play at least a positive modulatory role in the activation of Drosophila TRP
The Hollywood Reporter
