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PMID: 34687865 Biomed Pharmacother Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes

Betaine supplementation has been used for over 40 years to support individuals with genetic defects of folate dependent remethylation because betaine is known to increase methionine concentration and aid homocysteine reduction

This patient's hyperacute 30-minute timeline to death and the lack of neutrophilic infiltrates on autopsy make bilateral bronchopneumonia unlikely

Metabolically constrained, potentially reversible dysfunction may be more amenable to strategies that restore mitochondrial fitness (e.g., redox modulation) and support lymphocyte recovery (e.g., IL-7/IL-15), whereas exhaustion-like states may require checkpoint modulation in combination with approaches that target upstream mitochondrial stress and the TOX/NR4Aepigenetic axis